Hematopoietic Stem Cell Transplantation And Ms

Hematopoietic stem cells make blood cells.

Hematopoietic stem cell transplantation and ms.

However no definitive prospective randomized studies comparing hct versus alternative therapies for ms have been completed. The development of hematopoietic and mesenchymal stem cell transplantation as an effective treatment for multiple sclerosis. Hsct hematopoietic stem cell transplantation attempts to reboot the immune system which is responsible for damaging the brain and spinal cord in ms. Some doctors use a type of stem cell treatment called hematopoietic stem cell transplantation hsct to treat rrms.

Am j stem cell. Fassas a et al. In hsct for ms hematopoietic blood cell producing stem cells which are derived from a person s own scientifically referred to as autologous bone marrow or blood are collected and stored prior to depleting much of the. To assess in multiple sclerosis ms the effect of intense immunosuppression followed by autologous hematopoietic stem cells transplantation ahsct vs mitoxantrone mtx on disease activity measured by mri.

Several phase ii studies have been completed or are in progress. Hematopoietic stem cell transplantation hsct is the transplantation of multipotent hematopoietic stem cells usually derived from bone marrow peripheral blood or umbilical cord blood. It may be autologous the patient s own stem cells are used allogeneic the stem cells come from a donor or syngeneic from an identical twin. Burt performed the first hematopoietic stem cell transplant hsct for a multiple sclerosis ms patient in the united states at chicago s northwestern memorial hospital.

Hematopoietic stem cell transplantation hsct is a complicated and still. We conducted a multicenter phase ii randomized trial including patients with secondary progressive or relapsing remitting ms with a documented increase in the last. This left many in the ms community wondering about the specifics of this new and relatively unknown treatment for ms. Long term results of stem cell transplantation for ms.

For over a decade clinical investigation of autologous hematopoietic stem cell transplantation hct as therapy for multiple sclerosis ms has been ongoing.